Evaluation of medical countermeasures against organophosphorus compounds: The value of experimental data and computer simulations

Worek, Franz, Nadine Aurbek, Nadja M. Herkert, Harald John, Michael Eddleston, Peter Eyer, and Horst Thiermann. “Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations.” Chemico-biological interactions 187, no. 1 (2010): 259-264. abstract: Despite extensive research for more than six decades on medical countermeasures against poisoning by organophosphorus compounds … Continue Reading »

Pattern of pesticide storage before pesticide self-poisoning in rural Sri Lanka

Mohamed, Fahim, Gamini Manuweera, David Gunnell, Shifa Azher, Michael Eddleston, Andrew Dawson, and Flemming Konradsen. “Pattern of pesticide storage before pesticide self-poisoning in rural Sri Lanka.” BMC Public Health9, no. 1 (2009): 405. abstract: Background Deliberate self-poisoning with agricultural pesticides is the commonest means of suicide in rural Asia. It is mostly impulsive and facilitated by … Continue Reading »

Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning

Eyer, Peter, Franz Worek, Horst Thiermann, and Michael Eddleston. “Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning.” Chemico-biological interactions 187, no. 1 (2010): 270-278. abstract: It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction … Continue Reading »

A simple quantitative bedside test to determine methemoglobin

Shihana, Fathima, Dhammika Menike Dissanayake, Nicholas Allan Buckley, and Andrew Hamilton Dawson. “A simple quantitative bedside test to determine methemoglobin.” Annals of emergency medicine 55, no. 2 (2010): 184-189. abstract: Study objective Methemoglobinemia after pesticide poisoning is associated with a mortality of 12% in Sri Lanka. Treatment is complicated by the lack of laboratory facilities. We … Continue Reading »

Atropine therapy in acute anticholinesterase (Organophosphorus/carbamate) poisoning; adherence to current guidelines

Jayasinghe, S. S., A. Fernando, K. D. Pathirana, and K. Kishanthi Gunasinghe. “Atropine therapy in acute anticholinesterase (Organophosphorus/carbamate) poisoning; adherence to current guidelines.” Galle Medical Journal 14, no. 1 (2009): 26-30. abstract: Purpose: Atropine is a life saving drug in acute anticholinesterase poisoning. Proper atropinization is associated with better clinical outcome. Hence we aimed to … Continue Reading »

Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos

Eddleston, Michael, Franz Worek, Peter Eyer, Horst Thiermann, L. Von Meyer, K. Jeganathan, M. H. R. Sheriff, A. H. Dawson, and Nicholas A. Buckley. “Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos.” QJM 102, no. 11 (2009): 785-792. abstract: Background: Many organophosphorus (OP) insecticides have either two O-methyl or two O-ethyl groups attached to … Continue Reading »

A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning

Perera, P. M., Shaluka F. Jayamanna, Raja Hettiarachchi, Chandana Abeysinghe, Harindra Karunatilake, Andrew H. Dawson, and Nick A. Buckley. “A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning.” Trials 10, no. 1 (2009): 73. abstract: Background An estimated 2–3 million people are acutely poisoned by organophosphorus pesticides each … Continue Reading »

Relationship between blood alcohol concentration on admission and outcome in dimethoate organophosphorus self-poisoning

Eddleston, Michael, David Gunnell, Ludwig Von Meyer, and Peter Eyer. “Relationship between blood alcohol concentration on admission and outcome in dimethoate organophosphorus self‐poisoning.” British journal of clinical pharmacology 68, no. 6 (2009): 916-919. abstract: WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Acute alcohol intoxication often complicates acute organophosphorus pesticide poisoning. No data are available on … Continue Reading »

Auditory event-related potential changes in chronic occupational exposure to organophosphate pesticides

Dassanayake, T., I. B. Gawarammana, V. Weerasinghe, P. S. Dissanayake, S. Pragaash, A. Dawson, and N. Senanayake. “Auditory event-related potential changes in chronic occupational exposure to organophosphate pesticides.”Clinical Neurophysiology 120, no. 9 (2009): 1693-1698. abstract: Objective To determine whether chronic occupational exposure to organophosphates (OP) pesticides leads to cognitive impairment using event-related potentials (ERPs). Methods ERPs of … Continue Reading »

Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study

Zawahir, Shukry, Darren M. Roberts, Chathura Palangasinghe, Fahim Mohamed, Michael Eddleston, Andrew H. Dawson, Nick A. Buckley, Lingling Ren, Gregory A. Medley, and Indika Gawarammana. “Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study.”Clinical toxicology 47, no. 8 (2009): 792-797. abstract: Background Herbicides are commonly ingested for self-harm, … Continue Reading »