Deep coma and hypokalaemia of unknown aetiology following Bungarus caeruleus bites: Exploration of pathophysiological mechanisms with two case studies

Gawarammana, Indika Bandara, Senanayake Abeysinghe Mudiyanselage Kularatne, Keerthi Kularatne, Roshita Waduge, Vajira Senaka Weerasinghe, Sunil Bowatta, and Nimal Senanayake. “Deep coma and hypokalaemia of unknown aetiology following Bungarus caeruleus bites: Exploration of pathophysiological mechanisms with two case studies.” Journal of venom research 1 (2010): 71. abstract: Bungarotoxin present in Bungarus caeruleus (BC) causes life threatening … Continue Reading »

Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka

Wilks, Martin F., John A. Tomenson, Ravindra Fernando, P. L. Ariyananda, David J. Berry, NICHOLAS A. Buckley, Indika Bandara Gawarammana, Shaluka Jayamanne, David Gunnell, and Andrew Dawson. “Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka.”Clinical Toxicology 49, no. 1 (2011): 21-28. abstract: Introduction Deliberate self-harm with pesticides is a significant public … Continue Reading »

Trends in acute poisoning due to deliberate self-harm in the Southern Province of Sri Lanka

Ariyananda, P. L. “Trends in acute poisoning due to deliberate self-harm in the Southern Province of Sri Lanka.” Galle Medical Journal 15, no. 1 (2010): 17-24. click here for full text 

Acute human lethal toxicity of agricultural pesticides: a prospective cohort study

Dawson, Andrew H., Michael Eddleston, Lalith Senarathna, Fahim Mohamed, Indika Gawarammana, Steven J. Bowe, Gamini Manuweera, and Nicholas A. Buckley. “Acute human lethal toxicity of agricultural pesticides: a prospective cohort study.” PLoS medicine 7, no. 10 (2010): e1000357. abstract: Background Agricultural pesticide poisoning is a major public health problem in the developing world, killing at least … Continue Reading »

Clinical profile and outcome of patients hospitalized with dimethyl and diethyl organophosphate poisoning

Peter, John Victor, Jayakumar Jerobin, Anupama Nair, Anjana Bennett, Prasanna Samuel, Anugrah Chrispal, Ooriapadickal Cherian Abraham, Kuruvilla Prasad Mathews, Jude Joseph Fleming, and Anna Oommen. “Clinical profile and outcome of patients hospitalized with dimethyl and diethyl organophosphate poisoning.” Clinical toxicology 48, no. 9 (2010): 916-923. abstract: The two major classes of organophosphate compounds, dimethyl and … Continue Reading »

A modified low-cost colorimetric method for paracetamol (acetaminophen) measurement in plasma

Shihana, Fathima, Dhammika Dissanayake, Paul Dargan, and Andrew Dawson. “A modified low-cost colorimetric method for paracetamol (acetaminophen) measurement in plasma.” Clinical toxicology 48, no. 1 (2010): 42-46. abstract: Background Despite a significant increase in the number of patients with paracetamol poisoning in the developing world, plasma paracetamol assays are not widely available. The purpose of this … Continue Reading »

Bioscavenger therapy for organophosphate poisoning-an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans

Pichamuthu, Kishore, Jayakumar Jerobin, Anupama Nair, George John, Joseph Kamalesh, Kurien Thomas, Arun Jose et al. “Bioscavenger therapy for organophosphate poisoning-an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans.” Clinical Toxicology 48, no. 8 (2010): 813-819. abstract: Introduction Traditional treatment of organophosphate poisoning (OP) with oximes … Continue Reading »

The use of mid-trial reviews for design modifications in small scale clinical studies

Sooriyarachchi, M. R., R. V. Jayatillake, H. Ranganath, and Michael Eddleston. “The use of mid-trial reviews for design modifications in small scale clinical studies.” Contemporary clinical trials 31, no. 6 (2010): 579-586. abstract: Many clinical studies such as those in the areas of toxicology, early phase clinical trials and bioequivalence studies use small samples due … Continue Reading »

Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: A randomized controlled double blind study

Gawarammana, Indika, Fahim Mohamed, Steven J. Bowe, Ashoka Rathnathilake, Shantha K. Narangoda, Shifa Azher, Andrew H. Dawson, and Nick A. Buckley. “Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study.” BMC emergency medicine 10, no. 1 (2010): 15. abstract: Background Cardiac toxicity due to ingestion of oleander … Continue Reading »

Prospective policy analysis: how an epistemic community informed policymaking on intentional self poisoning in Sri Lanka.

Pearson, Melissa, Anthony B. Zwi, and Nicholas A. Buckley. “Research prospective policy analysis: How an epistemic community informed policymaking on intentional self poisoning in Sri Lanka.” Health Res. Policy Syst 8 (2010). abstract: Background Policy analysis is often retrospective and not well suited to helping policy makers decide what to do; in contrast prospective policy … Continue Reading »