Impact of paraquat regulation on suicide in South Korea.

Cha, E.S., Chang, S.S., Gunnell, D., Eddleston, M., Khang, Y.H. and Lee, W.J., 2016. Impact of paraquat regulation on suicide in South Korea. International journal of epidemiology, 45(2), pp.470-479. Abstract BACKGROUND: Ingestion of pesticides (mainly paraquat) accounted for one-fifth of suicides in South Korea in 2006-10. We investigated the effect on suicide mortality of regulatory … Continue Reading »

Development of a Snakebite risk map for Sri Lanka

Ediriweera, D.S., Kasturiratne, A., Pathmeswaran, A., Kithsiri, N., Gunawardena, B.A.W., Jayamanne, S.F., Kennedy, G., Isbister, A.D., Giorgi, E., Diggle, P.J. and Lalloo, D.G., Development of a Snakebite risk map for Sri Lanka. Introduction Snakebite is a neglected tropical disease Snakebite causes significant morbidity and mortality in poor rural communities Sri Lanka has 92 snake species … Continue Reading »

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom.

Villalta, M., Sánchez, A., Herrera, M., Vargas, M., Segura, Á., Cerdas, M., Estrada, R., Gawarammana, I., Keyler, D.E., McWhorter, K. and Malleappah, R., 2016. Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom. Toxicon. Abstract A new whole IgG, freeze-dried, … Continue Reading »

Arterial stiffness & Sri Lankan chronic kidney disease of unknown origin

Gifford, F., Kimmitt, R., Herath, C., Webb, D.J., Melville, V., Siribaddana, S., Eddleston, M. and Dhaun, N., 2016. Arterial stiffness & Sri Lankan chronic kidney disease of unknown origin.Scientific Reports, 6, p.32599. Abstract Chronic kidney disease (CKD) is common and independently associated with cardiovascular disease (CVD). Arterial stiffness contributes to CVD risk in CKD. In … Continue Reading »

Methemoglobin measurements are underestimated by the Radical 7 co-oximeter: experience from a series of moderate to severe propanil poisonings

Elspeth Hulse, Fathima Shihana, Nicholas A Buckley Abstract Introduction: In Asia methemoglobinemia (MetHb) is commonly caused through self-poisoning with the pesticide propranil. MetHb can cause hypoxia, coma and death, but usually responds to methylene blue. It is therefore vital to have accurate methods to measure blood MetHb to guide appropriate treatments. The gold standard to … Continue Reading »

A bedside test for methemoglobinemia, Sri Lanka

Shihana, F., Dawson, A.H. and Buckley, N.A., 2016. A bedside test for methemoglobinemia, Sri Lanka. Bulletin of the World Health Organization,94(8), p.622. Abstract Problem  Propanil is an aniline herbicide that is widely used for rice cultivation, but is also used for self-poisoning. Toxicity from propanil is largely due to methemoglobinemia. In resource-poor settings, the capacity to … Continue Reading »

Neurotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin

Silva, A., Kuruppu, S., Othman, I., Goode, R.J., Hodgson, W.C. and Isbister, G.K., 2016. Neurotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin.Neurotoxicity Research, pp.1-9. Abstract Russell’s vipers are snakes of major medical importance in Asia. Russell’s viper (Daboia russelii) envenoming in Sri Lanka and South India … Continue Reading »

Mapping the Risk of Snakebite in Sri Lanka – A National Survey with Geospatial Analysis

Ediriweera, D.S., Kasturiratne, A., Pathmeswaran, A., Gunawardena, N.K., Wijayawickrama, B.A., Jayamanne, S.F., Isbister, G.K., Dawson, A., Giorgi, E., Diggle, P.J. and Lalloo, D.G., 2016. Mapping the Risk of Snakebite in Sri Lanka-A National Survey with Geospatial Analysis. PLoS Negl Trop Dis, 10(7), p.e0004813. Abstract BACKGROUND: There is a paucity of robust epidemiological data on snakebite, … Continue Reading »

Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning.

Mohamed, F., Endre, Z.H., Pickering, J.W., Jayamanne, S., Palangasinghe, C., Shahmy, S., Chathuranga, U., Wijerathna, T., Shihana, F., Gawarammana, I. and Buckley, N.A., 2016. Mechanism-specific injury biomarkers predict nephrotoxicity early following glyphosate surfactant herbicide (GPSH) poisoning. Toxicology Letters. Abstract Acute kidney injury (AKI) is common following glyphosate surfactant herbicide (GPSH) self-poisoning. Serum creatinine (sCr) is … Continue Reading »

High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka – implications for global suicide prevention

Thomas Lamb, Liza R. Selvarajah, Fahim Mohamed, Shaluka Jayamanne, Indika Gawarammana, Ahmed Mostafa, Nicholas A. Buckley, Michael S. Roberts & Michael Eddleston Abstract High lethality and minimal variation after acute self-poisoning with carbamate insecticides in Sri Lanka – implications for global suicide prevention – Clinical Toxicology – Background: Highly hazardous organophosphorus (OP) insecticides are responsible … Continue Reading »