Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media

Zawahir, S., Gawarammana, I., Dargan, P.I., Abdulghni, M. and Dawson, A.H., 2017. Activated charcoal significantly reduces the amount of colchicine released from Gloriosa superba in simulated gastric and intestinal media. Clinical Toxicology, pp.1-5. Abstract Background: Poisoning with Gloriosa superba, a plant containing colchicine, is common in Sri Lanka. Objectives: This study was to estimate release of colchicine from 5 g … Continue Reading »

Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid

Wijerathna, T.M., Gawarammana, I.B., Dissanayaka, D.M., Palanagasinghe, C., Shihana, F., Dassanayaka, G., Shahmy, S., Endre, Z.H., Mohamed, F. and Buckley, N.A., 2017. Serum creatinine and cystatin C provide conflicting evidence of acute kidney injury following acute ingestion of potassium permanganate and oxalic acid. Clinical Toxicology, pp.1-7. Abstract Aim: Acute kidney injury (AKI) is common following deliberate self-poisoning … Continue Reading »

Nephrotoxicity-induced proteinuriaincreases biomarker diagnostic thresholdsin acute kidney injury

Fahim Mohamed1,2,3,4,8*, Nicholas A. Buckley1,4, John W. Pickering5,6, Klintean Wunnapuk7, Sandamali Dissanayake1,Umesh Chathuranga1, Indika Gawarammana1, Shaluka Jayamanne1 and Zoltan H. Endre3,5   Abstract Background: Paraquat ingestion is frequently fatal. While biomarkers of kidney damage increase during paraquat–induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent. This study evaluated … Continue Reading »

Is socioeconomic position associated with risk of attempted suicide in rural Sri Lanka? A cross-sectional study of 165 000 individuals

Knipe, D.W., Gunnell, D., Pieris, R., Priyadarshana, C., Weerasinghe, M., Pearson, M., Jayamanne, S., Dawson, A.H., Mohamed, F., Gawarammana, I. and Hawton, K., 2017. Is socioeconomic position associated with risk of attempted suicide in rural Sri Lanka? A cross-sectional study of 165 000 individuals. BMJ Open, 7(3), p.e014006. Abstract Background Lower socioeconomic position (SEP) is … Continue Reading »

Opportunities for pharmacists to optimise quality use of medicines in a Sri Lankan hospital: an observational, prospective, cohort study

Perera, D.M.P., Coombes, J.A., Shanika, L.G.T., Dawson, A., Lynch, C., Mohamed, F., De Silva, H.A., Jayamanne, S.F., Peters, N.B., Myers, B. and Coombes, I.D., 2017. Opportunities for pharmacists to optimise quality use of medicines in a Sri Lankan hospital: an observational, prospective, cohort study. Journal of Pharmacy Practice and Research. Abstract Background Quality use of … Continue Reading »

Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy

Pianta, T.J., Pickering, J.W., Succar, L., Chin, M., Davidson, T., Buckley, N.A., Mohamed, F. and Endre, Z.H., 2017. Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy. Kidney and Blood Pressure Research, 42(1), pp.62-75. Abstract Background/Aims: Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. … Continue Reading »

Plant Poisoning among Children in Rural Sri Lanka

Dayasiri, M.B., Jayamanne, S.F. and Jayasinghe, C.Y., 2017. Plant Poisoning among Children in Rural Sri Lanka. International Journal of Pediatrics, 2017. Abstract Plant poisoning is a common presentation in paediatric practice and an important cause of preventable mortality and morbidity in Sri Lanka. The burden of plant poisoning is largely underexplored. The current multicenter study … Continue Reading »

Suicide prevention through means restriction: Impact of the 2008-2011 pesticide restrictions on suicide in Sri Lanka

Knipe, D.W., Chang, S.S., Dawson, A., Eddleston, M., Konradsen, F., Metcalfe, C. and Gunnell, D., 2017. Suicide prevention through means restriction: Impact of the 2008-2011 pesticide restrictions on suicide in Sri Lanka. PLoS one, 12(3), p.e0172893. Abstract Objective: To investigate the effect of 3-year phased bans of the pesticides dimethoate and fenthion in 2008–2010, and … Continue Reading »

Endemic Nephropathy Around the World.

Gifford, F.J., Gifford, R.M., Eddleston, M. and Dhaun, N., 2017. Endemic Nephropathy Around the World. Kidney International Reports, 2(2), p.282. Abstract There have been several global epidemics of chronic kidney disease of unknown etiology (CKDu). Some, such as Itai-Itai disease in Japan and Balkan endemic nephropathy, have been explained, whereas the etiology of others remains … Continue Reading »

Regional variation in suicide rates in Sri Lanka between 1955 and 2011: a spatial and temporal analysis

Knipe, D.W., Padmanathan, P., Muthuwatta, L., Metcalfe, C. and Gunnell, D., 2017. Regional variation in suicide rates in Sri Lanka between 1955 and 2011: a spatial and temporal analysis. BMC public health, 17(1), p.193. Abstract Background Between 1955 and 2011 there were marked fluctuations in suicide rates in Sri Lanka; incidence increased six-fold between 1955 and the … Continue Reading »