Single fibre electromyography as a predictor of intermediate syndrome

Chanika Alahakoon, Tharaka Dassanayake, Indika Gawarammana, Michael Sedgwick, Vajira Weerasinghe Objectives: Deliberate self poisoning for suicidal purposes using organophosphorus insecticides (OPI) is common problem in Sri Lanka. The clinical sequence of OPI poisoning includes initial cholinergic crisis, intermediate syndrome (IMS) and delayed polyneuropathy. IMS is thought to be mediated via prolonged nicotinic receptor inhibition at … Continue Reading »

Re-visiting respiratory failure in acute organophosphorus insecticide self-poisoning in Sri Lanka

Chanika Alahakoon, Tharaka Dassanayake, Indika Gawarammana, Vajira Weerasinghe Objective: Deliberate self-poisoning with organophosphate insecticides (OPI) with a high incidence of morbidity and mortality is a problem in the developing world. Most of the deaths are associated with respiratory failure (RF) which occurs during cholinergic crisis or intermediate syndrome. To overcome this, certain highly toxic OPI … Continue Reading »

A Cluster RCT educational intervention on management of snakebites in Sri Lankan primary hospitals

Seyed Shahmy, Kularatne SAM, Andrew Dawson Objective: Snakebite has been identified as a neglected tropical disease. In Sri Lanka, 44,000 cases are reported annually. Most patients present to primary rural hospitals where health care workers have little access to ongoing education. To evaluate the effect on treatment of snakebite following a brief educational intervention. Methods: … Continue Reading »

Study of snakebite in Nawalpur snakebite treatment center, Netragunj, Sarlahi district, southcentral Nepal

Bhola Shrestha, Chhabilal Thapa-Magar, Deb Pandey Objective: To explore the snakebite burden, describe demographic condition, circumstances, seasonal patterns, care and outcomes of snakebite in south-central Nepal. Methods: We studied snakebites during 01 February through 31 July 2017 retrospectively using records maintained between July 2013 and January 2014. We analyzed data by means of descriptive statistics, … Continue Reading »

Mothers’ knowledge attitude and perception on side effects of medicines given for children- A qualitative study

Maneesha Prasadi, Lalith Senarathna, Samath Dharmaratne, Lakmini De Silva, Andrew Dawson Objective: This study aimed to assess mothers’ knowledge, attitude and perception on side effects of medicines given for children in southern province Sri Lanka. Method: Study participants were mothers who have children between age one to five years. This group was purposively selected from … Continue Reading »

Accuracy of referral hospital data to calculate the incident rate of Paracetamol poisoning in Sri Lanka

Vindya Pathiraja, Indika Gawarammana, Fahim Mohamed, Shaluka Jayamanna, Nicholas Buckley, Andrew Dawson Objective: Paracetamol admissions in Sri Lanka have been increasing in urban hospitals. The use has not been quantitated in rural areas. Increasing use in rural areas may impact on resource utilisation and public health. Official government statistics lump poisoning by drugs, medicaments and … Continue Reading »

Epidemiology of stings and bites in primary hospitals of Kurunegala district of Sri Lanka with emphasis on Hymenoptera stings

Seyed Shahmy, Kularatne SAM, SanjayaRathnayake, Andrew Dawson Objective: Stinging and bites are common environmental hazards that result in hospital admissions. However, the medical importance of this problem has not been fully evaluated in Sri Lanka. This study aimed to study epidemiology and clinical outcome of stings in all peripheral hospitals in the Kurunegala district of … Continue Reading »

In vivo efficacy and pharmacokinetics of a new Sri Lankan antivenom for Hump-nosed Viper (Hypnale spp) bites – A preliminary dosing study

Nandita Mirajkar, Ruwan Premathilake, Jose Maria Gutierrez,Indika Gawarammana, Geoff Isbister Objective: This study aimed to investigate the in vivo efficacy of a new antivenom for hump-nosed viper (Hypnale) envenomation at two different doses. In addition, it aimed to determine the pharmacokinetics and safety of the antivenom. Methods: Twenty suspected hump-nosed viper bites were recruited from … Continue Reading »

Quality Assessment of Economic Evaluations of Suicide and Self-Harm Interventions

Madsen, L.B., Eddleston, M., Hansen, K.S. and Konradsen, F., 2017. Quality Assessment of Economic Evaluations of Suicide and Self-Harm Interventions. Crisis. Abstract Background: Death following self-harm constitutes a major global public health challenge and there is an urgent need for governments to implement cost-effective, national suicide prevention strategies. Aim: To conduct a systematic review and quality appraisal of … Continue Reading »

A prospective cohort study of the effectiveness of the primary hospital management of all snakebites in Kurunegala district of Sri Lanka

Shahmy, S., Kularatne, S.A., Rathnayake, S.S. and Dawson, A.H., 2017. A prospective cohort study of the effectiveness of the primary hospital management of all snakebites in Kurunegala district of Sri Lanka. PLOS Neglected Tropical Diseases, 11(8), p.e0005847. Abstract Introduction Sri Lanka records substantial numbers of snakebite annually. Primary rural hospitals are important contributors to health care. Health … Continue Reading »