Where is the evidence for treatments used in pesticide poisoning? Is clinical toxicology fiddling while the developing world burns?

Buckley, Nicholas A., Lakshman Karalliedde, Andrew Dawson, Nimal Senanayake, and Michael Eddleston. “Where is the evidence for treatments used in pesticide poisoning? Is clinical toxicology fiddling while the developing world burns?.” Clinical Toxicology 42, no. 1 (2004): 113-116. read more here

Secondary contamination in organophosphate poisoning

Roberts, D., and L. Senarathna. “Secondary contamination in organophosphate poisoning.” QJM 97, no. 10 (2004): 697-698. Sir, We read with interest the article by Stacey et al. discussing their experience with treatment of organophosphate/organophosphorus (OP) pesticide poisoning.1 This is an important topic, given the large number of exposures and deaths from poisoning with this class … Continue Reading »

Refractory status epilepticus following self-poisoning with the organochlorine pesticide endosulfan

Roberts, Darren M., Wasantha Dissanayake, MH Rezvi Sheriff, and Michael Eddleston. “Refractory status epilepticus following self-poisoning with the organochlorine pesticide endosulfan.” Journal of Clinical Neuroscience 11, no. 7 (2004): 760-762. summary: We describe a case of refractory status epilepticus presenting to a rural general hospital in Sri Lanka. This patient’s condition was precipitated by intentional … Continue Reading »

Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil-a GABAA-gated chloride channel blocker

Mohamed, Fahim, Lalith Senarathna, Adrian Percy, Manel Abeyewardene, Geoffrey Eaglesham, Ron Cheng, Shifa Azher et al. “Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil-a GABAA-gated chloride channel blocker.” Clinical Toxicology 42, no. 7 (2004): 955-963. objective: Fipronil, a broad spectrum N‐phenylpyrazole insecticide that inhibits GABAA‐gated chloride channels, has been in use since the mid‐1990s. A … Continue Reading »

Overcoming apathy in research on organophosphate poisoning

Buckley, Nick A., Darren Roberts, and Michael Eddleston. “Overcoming apathy in research on organophosphate poisoning.” BMJ: British Medical Journal 329, no. 7476 (2004): 1231. abstract: High rates of pesticide poisoning in developing countries and increasing risk of nerve gas attacks in the West mean effective antidotes for organophosphates should be a worldwide priority Organophosphate pesticide … Continue Reading »

Speed of initial atropinisation in significant organophosphorus pesticide poisoning-a systematic comparison of recommended regimens

Eddleston, Michael, Nick A. Buckley, Helaina Checketts, Lalith Senarathna, Fahim Mohamed, MH Rezvi Sheriff, and Andrew Dawson. “Speed of initial atropinisation in significant organophosphorus pesticide poisoning-a systematic comparison of recommended regimens.” Clinical Toxicology 42, no. 6 (2004): 865-875. objective: Early deaths from organophosphorus (OP) pesticide self‐poisoning result from respiratory failure and cardiovascular collapse. Therapy requires … Continue Reading »

Early management after self-poisoning with an organophosphorus or carbamate pesticide-a treatment protocol for junior doctors

Eddleston, Michael, Andrew Dawson, Lakshman Karalliedde, Wasantha Dissanayake, Ariyasena Hittarage, Shifa Azher, and Nick A. Buckley. “Early management after self-poisoning with an organophosphorus or carbamate pesticide–a treatment protocol for junior doctors.” Critical Care 8, no. 6 (2004): R391. abstract: Severe organophosphorus or carbamate pesticide poisoning is an important clinical problem in many countries of the … Continue Reading »

Self poisoning with pesticides

Eddleston M, Phillips MR. Self poisoning with pesticides. BMJ : British Medical Journal. 2004;328(7430):42-44. abstract: WHO’s recent recommendations on reducing deaths from self harm will not help cut the high death rate from self poisoning in the Asia Pacific region Self inflicted violence accounts for around half of the 1.6 million violent deaths that occur every … Continue Reading »