Food spectrum of Common Krait (Bungarus caeruleus): implications for snakebite prevention and snake conservation

Deb P. Pandey, Pranish Bhattarai, Ram C. Piya Objectives: To examine food contents in the gut of dead kraits involved or not involved in snakebite to determine their most favored prey animals. Methods: We examined the gut of 34 dead common kraits (Bungarus caeruleus) preserved in collections maintained in hospitals and museums during July 2016 … Continue Reading »

Neuromuscular junction dysfunction in paraquat

Sudheera Jayasinghe, Kithsiri Pathirana, Andrew Dawson, Nick Buckley Objective: Paraquat is a non-selective, highly effective contact herbicide that has been widely used in many countries during the last 50 years. It has a very good safety profile if used properly. There are evidences that oxidative stress can cause neuromuscular dysfunction. Since the main pathology behind … Continue Reading »

Getting better value out of smaller sized clinical trials

Nicholas A. Buckley There is a need for greater understanding of good clinical research practice, methodology and critical appraisal. There should be a commitment to provide more good quality evidence through RCTs. It is important for such trials to be registered and be reported using CONSORT guidelines. These are all well recognised principles within the … Continue Reading »

The clinical toxicity of Imidacloprid self-poisoning following the introduction of newer formulations

Varan Perananthan, Fahim Mohamed, Seyed Shahmy, Indika Gawarammana, Andrew Dawson, Nicholas Buckley Objective: Self-poisoning with Imidacloprid has been previously shown to have low toxicity in humans. Since 2007 newer formulations of Imidacloprid with unknown solvents have been introduced. Kohinoor Imidacloprid (2007), Provado Imidacloprid (2007) and Gaucho 70 WS (2009) are common newer formulations introduced and … Continue Reading »

Association between co-ingested alcohol and deliberate self-poisonings

Jeevan Dhanarisi, Indika Gawarammana, Seyed Shahmy, Vindya Pathiraja, Fahim Mohamed, Michael Eddleston Objective: Sri Lanka has one of the highest alcohol consumption rates in the world. Acute use of alcohol is a potent risk factor for deliberate self-harm, though the nature of this risk is poorly understood. The aim of this study was to compare … Continue Reading »

Pilot study assessing gut toxicity in acute self-poisoning using a novel biomarker Intestinal Fatty Acid Binding Protein

Varan Perananthan, Thilini Wijerathna, Fahim Mohamed, Indika Gawarammana, Andrew Dawson, Nicholas Buckley Objective: Gut toxicity or reactive gastropathy is expected following oral ingestion of various toxins. However, the extent of enterocyte damage has not been previously quantified. Intestinal Fatty Acid Binding Protein (I-FABP) is a cystolic protein specific to intestinal epithelial cells that are released … Continue Reading »

Medicinal overdoses in Sri Lanka: Associated factors – a qualitative study

Lakmini De Silva, Andrew Dawson, Sampath Tennakoon, Indika Gawarammana, Thilini Rajapakse Objective: Attempted or non-fatal self-poisoning is a major public health problem in Sri Lanka. The objective of this study was to explore the factors associated with the self-poisoning behavior of those who have ingested a medicinal overdose. Methods: This was a qualitative study. Semi-structured … Continue Reading »

Gut toxicity in Russell’s and hump-nosed Viper envenomation

Varan Perananthan, Thilini Wijerathne, Fahim Mohamed, Indika Gawarammana, Andrew Dawson, Nicholas Buckley Objective: Abdominal pain is known to be an early clinical predictor of severe systemic Russell’s Viper (RV) envenomation and is often associated with the later development of coagulopathy and neurotoxicity. The mechanism of abdominal pain still remains unknown, but might be due to … Continue Reading »

Single fibre electromyography as a predictor of intermediate syndrome

Chanika Alahakoon, Tharaka Dassanayake, Indika Gawarammana, Michael Sedgwick, Vajira Weerasinghe Objectives: Deliberate self poisoning for suicidal purposes using organophosphorus insecticides (OPI) is common problem in Sri Lanka. The clinical sequence of OPI poisoning includes initial cholinergic crisis, intermediate syndrome (IMS) and delayed polyneuropathy. IMS is thought to be mediated via prolonged nicotinic receptor inhibition at … Continue Reading »

Re-visiting respiratory failure in acute organophosphorus insecticide self-poisoning in Sri Lanka

Chanika Alahakoon, Tharaka Dassanayake, Indika Gawarammana, Vajira Weerasinghe Objective: Deliberate self-poisoning with organophosphate insecticides (OPI) with a high incidence of morbidity and mortality is a problem in the developing world. Most of the deaths are associated with respiratory failure (RF) which occurs during cholinergic crisis or intermediate syndrome. To overcome this, certain highly toxic OPI … Continue Reading »