Research Grant Title:
Acute organophosphorus pesticide poisoning in Sri Lanka- management, complications and pharmaco-genetics.
Application ID: Wellcome Trust GR063560MA (Personal Fellowship)
Chief Investigator: Dr. Michael Eddleston
Administering Institution: Oxford University
Funding period: 2001-2005
Summary of the project:
The aim of this project is to establish a cohort of around 5000 acutely poisoned patients. Following are specific aims
- Whether activated charcoal reduces fatality rates in patients with any forms of acute poisoning. First study was a randomized controlled trial of single or multi-dose activated charcoal regimens in patients presenting with a history of acute poisoning. The study had looked at unselected adult patients with most forms of acute poisoning (ISRCTN 02920054). The main hypothesis of the study was that the multi-dose activated charcoal regimen reduces the case fatality rate from 10% to 7%
- Whether pralidoxime reduces the fatality rates in in symptomatic OP poisoned patients. Second study was a double-blind randomized controlled trial (RCT) of pralidoxime in adult patients presenting with a history and symptoms of organophosphate (OP) poisoning. Primary outcome was the in-hospital mortality; secondary outcomes were occurrence of serious complications (respiratory arrest, intermediate syndrome) and time requiring assisted ventilation (ISRCTN 55264358). The main hypothesis of this study was that the pralidoxime reduces the case fatality rate from 25% to 19%.
- The incidence of acute parkinsonism and the intermediate syndrome in patients with OP poisoning with or without pralidoxime treatment
- The incidence of complications in patients receiving activated charcoal
- Whether published severity scores predict outcome
- The influence of polymorphism in cytochrome p-450, glutathione S-transferase and paroxanse genes on clinical outcome
Progress of the grant: Completed and published |
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