Antivenom Grant

NHMRC Centre of Research Excellence (CRE) in Translational Venom and Antivenom Research

Program Grant ID: 1110343 NHMRC
Chief Investigators: Geoffrey Isbister, Nick Buckley, Janaka de Silva, Simon Brown, Wayne Hodgson, David Lalloo, Asita de Silva, Andrew Dawson, Indika Gawarammana, Andis Graudins
Administering Institutions: University of Newcastle, University of Sydney, University of Kelaniya, University of Western Australia, Monash University, Liverpool University, University of Peradeniya
Funding period: 2016 – 2020

The CRE will focus on snake envenoming, because it is the major contributor to the global burden of envenoming, and the effectiveness and safety of antivenom. An important aim will be to re-evaluate antivenoms from their in vitro binding capacity to their ability to improve outcomes in patients with envenoming. Another key issue is the identification of envenoming early because there is increasing evidence that early administration of antivenom is key to good outcomes. Finally, the CRE will aim to develop research capacity at all levels in South Asia and encourage research training in clinical toxicology in Australia. The CRE will also research and put into practice translational approaches to educating both health care workers in Australia and South Asia.

The CRE will be a combination of virtual networks coordinating multicenter randomised controlled trials and observational studies in Australia and Sri Lanka, and venom and antivenom laboratory research at three sites in Australia and one site in Sri Lanka.

This CRE in Translation of Venom and Antivenom Research aims to:

    1. Further develop basic venom and antivenom research that focuses on delineating mechanisms of envenoming and determining the efficacy of antivenoms in in vitro and animal models
    2. Develop laboratory and bedside tests for the diagnosis of envenoming
    3. Undertake clinical trials of antivenom and adjunct therapies in envenoming syndromes in Australia and South Asia
    4. Investigate reactions to venom and antivenom to improve our understanding of the immune response to venom and antivenom so as to improve the safety of antivenom
    5. Translate the results of basic and clinical research into clinical practice by training health care professionals but also undertaking specific educational studies in South Asia.