Closed Grants

Reducing deaths from pesticide poisoning – Establishing a regional toxicology research centre (Program Grant)

Program Grant ID: NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Chief Investigators: Nicholas Buckley/Nimal Senanayake
Administering Institution: Australian National University
Funding period: June 2004 to June 2011

This project, proposed to establish an Australian/Sri Lankan based research collaboration to evaluate methods to reduce deaths from deliberate self-poisoning with pesticides, was effectually the beginning of the South Asian Clinical Toxicology Research Collaboration.

This grant was awarded for the study of the effectiveness of a clinical research program such as SACTRC in understanding, reducing and preventing pesticide poisoning and in turn, morbidity and mortality from these conditions in Sri Lanka.


Acute organophosphorus pesticide poisoning in Sri Lanka- management, complications and pharmaco-genetics

Project Grant ID: Wellcome Trust GR063560MA (Personal Fellowship)
Chief Investigator: Michael Eddleston
Administering Institution: Oxford University
Funding period: 2001 to 2005

The aim of this project was to establish a cohort of around 5000 acutely poisoned patients. A first study to determine whether activated charcoal reduces fatality rates in patients with any forms of acute poisoning was a randomized controlled trial of single or multi-dose activated charcoal regimens in patients presenting with a history of acute poisoning. The second study, a double-blind RCT, aimed to determine whether pralidoxime in adult patients presenting with a history of symptoms of organophosphate (OP) poisoning reduced fatality rates.

Michael Eddlestons first large-scale study in Sri Lanka drew attention of the international scientific community to Sri Lanka, making way for the establishment of the South Asian Clinical Toxicology Research Collaboration.