Program Grant

An integrated research program in human toxicology to ensure rapid translation of results into practice and regulation

Program Grant ID: 1055176 NHMRC 
Chief Investigators: Nicholas Buckley, Andrew Dawson, Mike Roberts, Geoff Isbister
Administering Institutions: University of New South Wales, University of Sydney, University of Queensland, University of Newcastle 
Funding period: 2014 – 2018

This research project covers many areas in human toxicology including acute and chronic medicine and chemical poisoning, serious adverse drug reactions and toxinology. This grant aims to establish a research program that can provide a rapid, broad, flexible, international and integrated response to a range of human toxicology problems. In addition, it also aims to rapidly translate new research finding into regulation, policy and clinical practice through the existing strong relationship with various stake holders.   This program works on following general themes to address important research questions:

  1. Improved detection of emerging toxicological issues in humans (toxicovigilance)
  2. Understanding toxicological mechanisms behind differential toxicity in humans
  3. Improved management of clinical toxicological problems
  4. Providing the clinical toxicology data to facilitate public-health and regulatory responses

A few specific objectives from the long list of objectives within these four themes include:

  1. Determine the mechanisms that explain important differences in relative toxicity within drug and pesticide classes.
  2. Refine the treatment of the most common toxicology problems in Australia/Asia (e.g. snakebite, paracetamol, agrochemicals, psychotropics), especially where the current clinical strategies are unclear or where patient treatment may be unnecessarily prolonged.
  3. Using observed safe and toxic acute and chronic exposures in patients validate or highlight problems with predictions of thresholds used in the regulatory approval of various drugs/chemicals.