Research Projects

A complete list of all research projects undertaken by SACTRC academics:

ongoing projects

Title Applicant Funding Body/Grant ID
A randomised clinical trial of oral vs intravenous antidotes for paracetamol poisoning Indika Gawarammana
Socioeconomic influences on suicidal behaviour in Low and Middle Income (LAMIC) countries: a cohort study based on 53,000 households in Sri Lanka MDW Knipe WT099874MA
Determination of Palatability in Different dosage forms of oral N-acetylcystine and methionine with in a healthy volunteer group Vindya Pathiraja NHMRC/1055176
The value of serum and urinary biomarkers for early detection of acute kidney injury (AKI) in rats following injection of Daboia, Echis and Hypnale venom Eranga Wijewickrama NHMRC/1011772
A pilot study of rocuronium to prevent intermediate syndrome after organophosphorus insecticide poisoning Indika Gawarammana NHMRC/1030069
A pilot study to investigate a. the pulmonary injury created by both ingested and aspirated pesticide during self-poisoning and b. potential biomarkers to indicate pesticide poisoning and/or aspiration Indika Gawarammana NHMRC/1030069
Anticholinesterase (Organphosphorus or Carbamate) Insecticides or Herbicides on Pancreatic Function: A Feasibility Study Michael Eddleston University of Copenhagen
A qualitative investigation of alcohol’s role in self-harm in rural Sri Lanka Jane Brandt Sorensen University of Copenhagen
Preventing pesticide suicides by restricting access through vendors – exploratory and pilot studies Manjula Weerasinghe American Foundation for Suicide Prevention
A cluster ranomized controlled trial of educational intervention on management of snake bite in the North Western province of Sri Lanka S. A. M. Kularatne NHMRC/630650
Effectiveness of life skills training program in preventing common issues among adolescents: a community based quasi experimental study Janaka Pushpakumara NHMRC/630650
Development of clinical vignettes and pilot testing of a vignette based methodology to measure effect of contextual factors on clinical decision making in rural primary care setting Sisira Dharmaratne NHMRC/630650
Pattern of deliberate self-harm in Kurunegala district, Sri Lanka Janaka Pushpakumara NHMRC/630650
A cluster RCT educational interventions on treatment of patients with acute poisoning in rural asian hospitals Andrew Dawson NHMRC/630650
Russell’s viper coagulopathy – fresh frozen plasma study Geoff Isbister NHMRC 631073
Safer Storage of Agrochemicals in the Community: Evaluation of its impact on fatal and non-fatal poisoning Shaluka Jayamanne Welcome Trust/090958
A hospital based cluster randomized controlled trial to evaluate treatment behaviour following educational interventions and essential antidote stocking in the treatment of acute poisoning patients (Short Title: Evaluation of Primary Hospital Educational Intervention) Indika Gawarammana NHMRC/630650
A multi-centre follow-up study on the health effects following acute poisoning in Sri Lanka Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
A multi-centre observational study on the health effects and clinical features of acute self-poisoning in Sri Lanka Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)

recently completed projects (pending publication)

Title Applicant Funding Body/Grant ID
Pilot study to evaluate the effectiveness of direct community educational programs to improve responses to medical emergencies within the community and to change the community perception on peripheral hospital treatments Indika Gawarammana NHMRC/630650
The role and the practices of nurses in rural hospital health care team in Sri Lanka Lakmini de Silva NHMRC/630650
The Impact on the quality use of medicines of adding clinical pharmacists to a medical team in a Sri Lankan Teaching Hospital Asita De Silva NHMRC/630650
Does high dose immunosuppression with cyclophosphamide, methylprednisolone and dexamethasone reduce death due to lung fibrosis following ingestion of paraquat? Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
A study of investigations that may predict the outcome in paraquat poisoning Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)

completed projects

Title Applicant Funding Body/Grant ID
Measurement of novel urinary bio-markers of acute kidney injury caused by nephrotoxins Indika Gawarammana NHMRC/1011772
Use of intravenous acetylsalicylic acid (‘Aspirin’) as a novel antidote for human paraquat poisoning – can it reduce 70% mortality rate and oxidative stress? Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Compassionate use of fructose-1, 6-diphosphate (FDP) in treating severe yellow oleander-induced cardiac toxicity Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Antivenom serum (AVS) dose finding study in Russell’s Viper and Krait envenoming Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Postmortem studies of pesticide self-poisoning Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
The use of bedside acetylcholinesterase test in guiding the treatment of Organophosphorus Poisoned patients Bishan Rajapakse NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Pilot Study of Treatment of Propanil Poisoning induced Methaemoglobinaemia with Methylene Blue bolus followed by titrate low dose infusion Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Are patients with symptomatic organophosphate poisoning pottassium depleted? Indika Gawarammana NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Can antioxidants reduce the mortality in paraquat poisoning? Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Is clonidine an effective treatment for organophosphate poisoning? Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Is magnesium an effective treatment for organophosphate poisoning? Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)
Can fructose 1, 6-diphosphate (FDP) reverse yellow oleander-induced cardiac toxicity? Andrew Dawson NHMRC 268053 Wellcome Trust GR071669MA (International Collaborative Research grant scheme)